Assay Detail
Functional
CHEMBL5037542
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Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell proliferation measured after 3 days by Cell Titer-Glo luminescence based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-51 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.97 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093015 | — | — | 1 | 8.40 |
| CHEMBL5085182 | — | — | 1 | 8.30 |
| CHEMBL5081270 | — | — | 1 | 8.22 |
| CHEMBL5079606 | — | — | 1 | 8.15 |
| CHEMBL5081668 | — | — | 1 | 8.10 |
| CHEMBL5086022 | — | — | 1 | 8.05 |
| CHEMBL5073101 | — | — | 1 | 8.00 |
| CHEMBL5075313 | — | — | 1 | 8.00 |
| CHEMBL5092826 | — | — | 1 | 8.00 |
| CHEMBL5087340 | — | — | 1 | 7.96 |
| CHEMBL5077627 | — | — | 1 | 7.92 |
| CHEMBL5085753 | — | — | 1 | 7.80 |
| CHEMBL5085278 | — | — | 1 | 7.77 |
| CHEMBL5086435 | — | — | 1 | 7.77 |
| CHEMBL5077668 | — | — | 1 | 7.72 |
| CHEMBL5084062 | — | — | 1 | 7.70 |
| CHEMBL5091689 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093015 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5085182 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5081270 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5079606 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5081668 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5086022 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5073101 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5075313 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5092826 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5087340 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5077627 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5085753 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5085278 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5086435 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5077668 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5084062 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5091689 | — | IC50 | = | 22.0 | nM | 7.66 |