Assay Detail
Binding
CHEMBL5037827
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Inhibition of SARS CoV-2 papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 50 mins by multimode plate reader method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.98 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5070941 | — | — | 1 | 6.17 |
| CHEMBL549695 | — | — | 1 | 5.78 |
| CHEMBL5091761 | — | — | 1 | - |
| CHEMBL5085757 | — | — | 1 | - |
| CHEMBL5087131 | — | — | 1 | - |
| CHEMBL5093511 | — | — | 1 | - |
| CHEMBL5076044 | — | — | 1 | - |
| CHEMBL5092252 | — | — | 1 | - |
| CHEMBL5088813 | — | — | 1 | - |
| CHEMBL5093125 | — | — | 1 | - |
| CHEMBL5080077 | — | — | 1 | - |
| CHEMBL5077268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5070941 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL549695 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL5091761 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5085757 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5087131 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5093511 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5076044 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5092252 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5088813 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5093125 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5080077 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5077268 | — | IC50 | > | 25000.0 | nM | - |