Assay Detail
Functional
CHEMBL5037829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.63 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5080077 | — | — | 1 | 6.36 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 6.21 |
| CHEMBL5070941 | — | — | 1 | 5.86 |
| CHEMBL5085757 | — | — | 1 | 5.70 |
| CHEMBL5088813 | — | — | 1 | 4.96 |
| CHEMBL5077268 | — | — | 1 | 4.70 |
| CHEMBL5091761 | — | — | 1 | - |
| CHEMBL5087131 | — | — | 1 | - |
| CHEMBL5093511 | — | — | 1 | - |
| CHEMBL5076044 | — | — | 1 | - |
| CHEMBL5092252 | — | — | 1 | - |
| CHEMBL5093125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5080077 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5070941 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5085757 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5088813 | — | EC50 | = | 10940.0 | nM | 4.96 |
| CHEMBL5077268 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5091761 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5087131 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL5093511 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL5076044 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL5092252 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5093125 | — | EC50 | > | 20000.0 | nM | - |