Assay Detail
Functional
CHEMBL5037906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against DENV2 New Guinea C strain infected in human Huh7 cells assessed as reduction in viral infection measured after 48 hrs post infection by renilla luciferase assay relative to control
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 57 | 5.58 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042321 | — | — | 1 | 8.55 |
| CHEMBL4454780 | — | — | 1 | 8.15 |
| CHEMBL1631361 | — | — | 1 | 7.16 |
| CHEMBL4759000 | — | — | 1 | 7.10 |
| CHEMBL5081798 | — | — | 1 | 6.60 |
| CHEMBL535429 | — | — | 1 | 6.23 |
| CHEMBL4781252 | — | — | 1 | 6.09 |
| CHEMBL5072753 | — | — | 1 | 5.89 |
| CHEMBL5075146 | — | — | 1 | 5.77 |
| CHEMBL4440586 | — | — | 1 | 5.52 |
| CHEMBL5077190 | — | — | 1 | 5.48 |
| CHEMBL5078686 | — | — | 1 | 5.42 |
| CHEMBL5076438 | — | — | 1 | 5.39 |
| CHEMBL5071224 | — | — | 1 | 5.39 |
| CHEMBL5085029 | — | — | 1 | 5.39 |
| CHEMBL5071184 | — | — | 1 | 5.37 |
| CHEMBL5089967 | — | — | 1 | 5.32 |
| CHEMBL5091744 | — | — | 1 | 5.30 |
| CHEMBL5077825 | — | — | 1 | 5.24 |
| CHEMBL5078159 | — | — | 1 | 5.23 |
| CHEMBL5091467 | — | — | 1 | 5.21 |
| CHEMBL5091321 | — | — | 1 | 5.21 |
| CHEMBL5077739 | — | — | 1 | 5.21 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.19 |
| CHEMBL304929 | — | — | 1 | 5.19 |
| CHEMBL5077924 | — | — | 1 | 5.17 |
| CHEMBL5080109 | — | — | 1 | 5.14 |
| CHEMBL65250 | — | — | 1 | 5.12 |
| CHEMBL5092707 | — | — | 1 | 5.11 |
| CHEMBL5083115 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042321 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4454780 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1631361 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4759000 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5081798 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL535429 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4781252 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5072753 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5075146 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4440586 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5077190 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5078686 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5085029 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5071224 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5076438 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5071184 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5089967 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5091744 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5077825 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5078159 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5091467 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5091321 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5077739 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL553 | ERLOTINIB | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL304929 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5077924 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5080109 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL65250 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5092707 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5083115 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5081658 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1092250 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL5078636 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5080420 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5074246 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5086028 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5086560 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5085316 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL98248 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5076415 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5084204 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5088695 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4446630 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5076833 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5077770 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5092280 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5089185 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5082591 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5093936 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5077521 | — | EC50 | > | 10000.0 | nM | - |