Assay Detail
Functional
CHEMBL5037940
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Cytotoxicity against human A673 cells measured after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A673 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.68 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650595 | AR-12 | 1.0 | 1 | 5.68 |
| CHEMBL5085987 | — | — | 1 | - |
| CHEMBL5092990 | — | — | 1 | - |
| CHEMBL3823844 | — | — | 1 | - |
| CHEMBL3600873 | MK-5108 | 1.0 | 1 | - |
| CHEMBL1234429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650595 | AR-12 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5085987 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5092990 | — | IC50 | - | — | - | |
| CHEMBL3823844 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3600873 | MK-5108 | IC50 | > | 30000.0 | nM | - |
| CHEMBL1234429 | — | IC50 | > | 30000.0 | nM | - |