Assay Detail
Binding
CHEMBL5038009
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Inhibition of B0AT1 (unknown origin) by FLIPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B<sup>0</sup>AT1 (SLC6A19).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.08 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93233 | CINROMIDE | 2.0 | 1 | 6.55 |
| CHEMBL5081254 | — | — | 1 | 5.72 |
| CHEMBL5088149 | — | — | 1 | 4.70 |
| CHEMBL116590 | — | — | 1 | 4.36 |
| CHEMBL5085749 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93233 | CINROMIDE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5081254 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5088149 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL116590 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL5085749 | — | IC50 | = | 90000.0 | nM | 4.05 |