Assay Detail
Functional
CHEMBL5038014
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Cytotoxicity against human SUM52 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter blue viability assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUM52PE |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.61 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189584 | PD-173074 | — | 1 | 8.10 |
| CHEMBL5085478 | — | — | 1 | 6.22 |
| CHEMBL5090566 | — | — | 1 | 6.16 |
| CHEMBL5083349 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189584 | PD-173074 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5085478 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5090566 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5083349 | — | IC50 | = | 1100.0 | nM | 5.96 |