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Assay Detail

CHEMBL5038236

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Functional
Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors.
Xue D, Xu Y, Kyani A, Roy J, Dai L, Sun D, Neamati N.
J Med Chem (2022) 65 : 343 -368
PubMed 34982568 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 64 5.89 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5085170 — — 1 7.40
CHEMBL5080477 — — 1 7.30
CHEMBL5077174 — — 1 7.30
CHEMBL5086428 — — 1 7.30
CHEMBL5088162 — — 1 7.16
CHEMBL5073716 — — 1 7.16
CHEMBL5079929 — — 1 7.16
CHEMBL5073778 — — 1 7.00
CHEMBL5076436 — — 1 7.00
CHEMBL5081607 — — 1 7.00
CHEMBL5084996 — — 1 6.72
CHEMBL5082002 — — 1 6.70
CHEMBL5082433 — — 1 6.70
CHEMBL5090136 — — 1 6.60
CHEMBL5083322 — — 1 6.52
CHEMBL5079239 — — 1 6.52
CHEMBL5089801 — — 1 6.40
CHEMBL5070773 — — 1 6.40
CHEMBL5078145 — — 1 6.22
CHEMBL5090789 — — 1 6.22
CHEMBL5085137 — — 1 6.10
CHEMBL5084330 — — 1 6.05
CHEMBL5079161 — — 1 6.05
CHEMBL5083790 — — 1 6.00
CHEMBL5083909 — — 1 6.00
CHEMBL5094937 — — 1 6.00
CHEMBL5084134 — — 1 5.89
CHEMBL5088642 — — 1 5.89
CHEMBL5093599 — — 1 5.75
CHEMBL5078578 — — 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5085170 — IC50 = 40.0 nM 7.40
CHEMBL5080477 — IC50 = 50.0 nM 7.30
CHEMBL5086428 — IC50 = 50.0 nM 7.30
CHEMBL5077174 — IC50 = 50.0 nM 7.30
CHEMBL5088162 — IC50 = 70.0 nM 7.16
CHEMBL5073716 — IC50 = 70.0 nM 7.16
CHEMBL5079929 — IC50 = 70.0 nM 7.16
CHEMBL5073778 — IC50 = 100.0 nM 7.00
CHEMBL5076436 — IC50 = 100.0 nM 7.00
CHEMBL5081607 — IC50 = 100.0 nM 7.00
CHEMBL5084996 — IC50 = 190.0 nM 6.72
CHEMBL5082002 — IC50 = 200.0 nM 6.70
CHEMBL5082433 — IC50 = 200.0 nM 6.70
CHEMBL5090136 — IC50 = 250.0 nM 6.60
CHEMBL5079239 — IC50 = 300.0 nM 6.52
CHEMBL5083322 — IC50 = 300.0 nM 6.52
CHEMBL5089801 — IC50 = 400.0 nM 6.40
CHEMBL5070773 — IC50 = 400.0 nM 6.40
CHEMBL5078145 — IC50 = 600.0 nM 6.22
CHEMBL5090789 — IC50 = 600.0 nM 6.22
CHEMBL5085137 — IC50 = 800.0 nM 6.10
CHEMBL5084330 — IC50 = 900.0 nM 6.05
CHEMBL5079161 — IC50 = 900.0 nM 6.05
CHEMBL5094937 — IC50 = 1000.0 nM 6.00
CHEMBL5083790 — IC50 = 1000.0 nM 6.00
CHEMBL5083909 — IC50 = 1000.0 nM 6.00
CHEMBL5084134 — IC50 = 1300.0 nM 5.89
CHEMBL5088642 — IC50 = 1300.0 nM 5.89
CHEMBL5093599 — IC50 = 1800.0 nM 5.75
CHEMBL5078578 — IC50 = 2300.0 nM 5.64
CHEMBL5070365 — IC50 = 2300.0 nM 5.64
CHEMBL5073309 — IC50 = 2500.0 nM 5.60
CHEMBL5069815 — IC50 = 2600.0 nM 5.58
CHEMBL5081198 — IC50 = 2600.0 nM 5.58
CHEMBL5081124 — IC50 = 2800.0 nM 5.55
CHEMBL5094474 — IC50 = 2900.0 nM 5.54
CHEMBL5079668 — IC50 = 3300.0 nM 5.48
CHEMBL5086389 — IC50 = 3400.0 nM 5.47
CHEMBL5081343 — IC50 = 4100.0 nM 5.39
CHEMBL5077241 — IC50 = 4600.0 nM 5.34
CHEMBL5085667 — IC50 = 4900.0 nM 5.31
CHEMBL5087476 — IC50 = 5100.0 nM 5.29
CHEMBL5093153 — IC50 = 5600.0 nM 5.25
CHEMBL5078204 — IC50 = 6200.0 nM 5.21
CHEMBL5091781 — IC50 = 6400.0 nM 5.19
CHEMBL5086282 — IC50 = 7400.0 nM 5.13
CHEMBL5082194 — IC50 = 7900.0 nM 5.10
CHEMBL5090864 — IC50 = 8600.0 nM 5.07
CHEMBL5086014 — IC50 = 8600.0 nM 5.07
CHEMBL5078041 — IC50 = 12100.0 nM 4.92