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Assay Detail

CHEMBL5038237

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BXPC-3
Confidence 1 — Organism
Curated By Autocuration

Target

BXPC-3 (CHEMBL614530)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors.
Xue D, Xu Y, Kyani A, Roy J, Dai L, Sun D, Neamati N.
J Med Chem (2022) 65 : 343 -368
PubMed 34982568 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 5.49 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5086428 1 6.92
CHEMBL5079929 1 6.70
CHEMBL5073778 1 6.52
CHEMBL5083322 1 6.52
CHEMBL5081607 1 6.52
CHEMBL5085170 1 6.52
CHEMBL5082433 1 6.40
CHEMBL5070773 1 6.22
CHEMBL5085137 1 6.19
CHEMBL5084996 1 6.05
CHEMBL5079161 1 6.00
CHEMBL5089801 1 5.96
CHEMBL5094937 1 5.92
CHEMBL5076436 1 5.85
CHEMBL5084134 1 5.85
CHEMBL5083790 1 5.80
CHEMBL5084330 1 5.80
CHEMBL5082002 1 5.75
CHEMBL5078578 1 5.60
CHEMBL5079239 1 5.58
CHEMBL5081198 1 5.58
CHEMBL5081343 1 5.54
CHEMBL5090789 1 5.48
CHEMBL5094474 1 5.48
CHEMBL5088642 1 5.48
CHEMBL5069815 1 5.44
CHEMBL5087476 1 5.25
CHEMBL5083909 1 5.17
CHEMBL5079668 1 5.16
CHEMBL5073309 1 5.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5086428 IC50 = 120.0 nM 6.92
CHEMBL5079929 IC50 = 200.0 nM 6.70
CHEMBL5083322 IC50 = 300.0 nM 6.52
CHEMBL5081607 IC50 = 300.0 nM 6.52
CHEMBL5085170 IC50 = 300.0 nM 6.52
CHEMBL5073778 IC50 = 300.0 nM 6.52
CHEMBL5082433 IC50 = 400.0 nM 6.40
CHEMBL5070773 IC50 = 600.0 nM 6.22
CHEMBL5085137 IC50 = 640.0 nM 6.19
CHEMBL5084996 IC50 = 900.0 nM 6.05
CHEMBL5079161 IC50 = 1000.0 nM 6.00
CHEMBL5089801 IC50 = 1100.0 nM 5.96
CHEMBL5094937 IC50 = 1200.0 nM 5.92
CHEMBL5084134 IC50 = 1400.0 nM 5.85
CHEMBL5076436 IC50 = 1400.0 nM 5.85
CHEMBL5083790 IC50 = 1600.0 nM 5.80
CHEMBL5084330 IC50 = 1600.0 nM 5.80
CHEMBL5082002 IC50 = 1800.0 nM 5.75
CHEMBL5078578 IC50 = 2500.0 nM 5.60
CHEMBL5079239 IC50 = 2600.0 nM 5.58
CHEMBL5081198 IC50 = 2600.0 nM 5.58
CHEMBL5081343 IC50 = 2900.0 nM 5.54
CHEMBL5090789 IC50 = 3300.0 nM 5.48
CHEMBL5094474 IC50 = 3300.0 nM 5.48
CHEMBL5088642 IC50 = 3300.0 nM 5.48
CHEMBL5069815 IC50 = 3600.0 nM 5.44
CHEMBL5087476 IC50 = 5600.0 nM 5.25
CHEMBL5083909 IC50 = 6700.0 nM 5.17
CHEMBL5079668 IC50 = 6900.0 nM 5.16
CHEMBL5073309 IC50 = 7400.0 nM 5.13
CHEMBL5085667 IC50 = 7700.0 nM 5.11
CHEMBL5078204 IC50 = 7700.0 nM 5.11
CHEMBL5093153 IC50 = 8000.0 nM 5.10
CHEMBL5090864 IC50 = 10000.0 nM 5.00
CHEMBL5086389 IC50 = 10100.0 nM 5.00
CHEMBL5091781 IC50 = 10500.0 nM 4.98
CHEMBL5082194 IC50 = 10800.0 nM 4.97
CHEMBL5073061 IC50 = 12700.0 nM 4.90
CHEMBL5091718 IC50 = 12900.0 nM 4.89
CHEMBL5078041 IC50 = 13300.0 nM 4.88
CHEMBL5086282 IC50 = 13400.0 nM 4.87
CHEMBL5070365 IC50 = 13800.0 nM 4.86
CHEMBL5086014 IC50 = 13800.0 nM 4.86
CHEMBL5081124 IC50 = 18500.0 nM 4.73
CHEMBL5080108 IC50 = 18500.0 nM 4.73
CHEMBL5082654 IC50 = 23100.0 nM 4.64
CHEMBL5079862 IC50 = 23400.0 nM 4.63
CHEMBL5077886 IC50 = 25200.0 nM 4.60
CHEMBL5084663 IC50 = 29300.0 nM 4.53
CHEMBL5090026 IC50 > 30000.0 nM -