Assay Detail
Functional
CHEMBL5038245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of oxidative phosphorylation in human MIA PaCa-2 cells assessed as reduction in ATP production incubated for 24 hrs in galactose-containing medium by CellTiter-glo luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.19 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5080477 | — | — | 1 | 7.76 |
| CHEMBL5073716 | — | — | 1 | 7.54 |
| CHEMBL5077174 | — | — | 1 | 7.51 |
| CHEMBL5088162 | — | — | 1 | 7.37 |
| CHEMBL5070773 | — | — | 1 | 6.93 |
| CHEMBL5070365 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5080477 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL5073716 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL5077174 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL5088162 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL5070773 | — | IC50 | = | 118.5 | nM | 6.93 |
| CHEMBL5070365 | — | IC50 | = | 951.0 | nM | 6.02 |