Assay Detail
Binding
CHEMBL5038464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mins by FRET assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
Identification of Slow-Binding Inhibitors of the BoNT/A Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.24 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | — | 1 | 6.52 |
| CHEMBL5077928 | — | — | 1 | 5.61 |
| CHEMBL5084806 | — | — | 1 | 5.55 |
| CHEMBL5093260 | — | — | 1 | 5.33 |
| CHEMBL5082512 | — | — | 1 | 5.20 |
| CHEMBL4776429 | — | — | 1 | 4.76 |
| CHEMBL4779141 | — | — | 1 | 4.59 |
| CHEMBL4741834 | — | — | 1 | 4.37 |
| CHEMBL5071456 | — | — | 1 | - |
| CHEMBL5082531 | — | — | 1 | - |
| CHEMBL5076439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL5077928 | — | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL5084806 | — | Ki | = | 2840.0 | nM | 5.55 |
| CHEMBL5093260 | — | Ki | = | 4660.0 | nM | 5.33 |
| CHEMBL5082512 | — | Ki | = | 6310.0 | nM | 5.20 |
| CHEMBL4776429 | — | Ki | = | 17200.0 | nM | 4.76 |
| CHEMBL4779141 | — | Ki | = | 25400.0 | nM | 4.59 |
| CHEMBL4741834 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL5071456 | — | Ki | > | 32000.0 | nM | - |
| CHEMBL5082531 | — | Ki | > | 16000.0 | nM | - |
| CHEMBL5076439 | — | Ki | > | 8000.0 | nM | - |