Assay Detail
Binding
CHEMBL5038533
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Inhibition on hERG expressed in HEK293 cells by Qpatch method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.32 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091818 | — | — | 1 | 5.44 |
| CHEMBL5091051 | — | — | 1 | 5.43 |
| CHEMBL5074659 | — | — | 1 | 5.42 |
| CHEMBL5075517 | — | — | 1 | 5.40 |
| CHEMBL5092554 | — | — | 1 | 5.35 |
| CHEMBL5091256 | — | — | 1 | 5.34 |
| CHEMBL5081532 | — | — | 1 | 5.25 |
| CHEMBL5087053 | — | — | 1 | 5.13 |
| CHEMBL5089676 | — | — | 1 | 5.08 |
| CHEMBL5089702 | — | — | 1 | - |
| CHEMBL5072152 | — | — | 1 | - |
| CHEMBL5072616 | — | — | 1 | - |
| CHEMBL5072213 | — | — | 1 | - |
| CHEMBL5082744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091818 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5091051 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5074659 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5075517 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL5092554 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL5091256 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL5081532 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL5087053 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL5089676 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL5089702 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072152 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072213 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5082744 | — | IC50 | > | 10000.0 | nM | - |