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Assay Detail

CHEMBL5038558

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Venezuelan equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Venezuelan equine encephalitis virus
Cell Type Vero 76
Confidence 1 — Organism
Curated By Autocuration

Target

Venezuelan equine encephalitis virus (CHEMBL613726)
Type ORGANISM
Organism Venezuelan equine encephalitis virus

Publication

Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones.
Ryan MC, Kim E, Cao X, Reichard W, Ogorek TJ, Das P, Jonsson CB, Baudry J, Chung D, Golden JE.
ACS Med Chem Lett (2022) 13 : 546 -553
PubMed 35450382 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 5.98 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5086104 1 7.39
CHEMBL5084707 1 7.32
CHEMBL5080159 1 6.92
CHEMBL5081454 1 6.82
CHEMBL5073057 1 6.62
CHEMBL5086133 1 6.48
CHEMBL5080706 1 6.30
CHEMBL5084039 1 6.28
CHEMBL5094162 1 5.60
CHEMBL5077889 1 5.52
CHEMBL5080705 1 5.39
CHEMBL5090302 1 5.38
CHEMBL5081936 1 5.33
CHEMBL5091960 1 5.25
CHEMBL5072900 1 5.16
CHEMBL5087708 1 5.16
CHEMBL5079242 1 4.70
CHEMBL5077209 1 -
CHEMBL5077885 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5086104 EC50 = 41.0 nM 7.39
CHEMBL5084707 EC50 = 48.0 nM 7.32
CHEMBL5080159 EC50 = 120.0 nM 6.92
CHEMBL5081454 EC50 = 150.0 nM 6.82
CHEMBL5073057 EC50 = 240.0 nM 6.62
CHEMBL5086133 EC50 = 330.0 nM 6.48
CHEMBL5080706 EC50 = 500.0 nM 6.30
CHEMBL5084039 EC50 = 530.0 nM 6.28
CHEMBL5094162 EC50 = 2500.0 nM 5.60
CHEMBL5077889 EC50 = 3000.0 nM 5.52
CHEMBL5080705 EC50 = 4100.0 nM 5.39
CHEMBL5090302 EC50 = 4200.0 nM 5.38
CHEMBL5081936 EC50 = 4700.0 nM 5.33
CHEMBL5091960 EC50 = 5600.0 nM 5.25
CHEMBL5072900 EC50 = 7000.0 nM 5.16
CHEMBL5087708 EC50 = 7000.0 nM 5.16
CHEMBL5079242 EC50 = 19800.0 nM 4.70
CHEMBL5077209 EC50 > 30000.0 nM -
CHEMBL5077885 EC50 > 30000.0 nM -