Assay Detail
Binding
CHEMBL5039255
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Inhibition of SARS-CoV2 3C-like protease expressed in Escherichia coli BL21 (DE3) cells using Mca-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorogenic substrate incubated for 10 mins by FRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.06 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076204 | — | — | 1 | 7.47 |
| CHEMBL5092077 | — | — | 1 | 7.23 |
| CHEMBL5084942 | — | — | 1 | 7.19 |
| CHEMBL5094273 | — | — | 1 | 7.17 |
| CHEMBL5093941 | — | — | 1 | 7.17 |
| CHEMBL5087722 | — | — | 1 | 7.17 |
| CHEMBL5087004 | — | — | 1 | 7.11 |
| CHEMBL5092841 | — | — | 1 | 7.10 |
| CHEMBL5078067 | — | — | 1 | 7.01 |
| CHEMBL5082778 | — | — | 1 | 6.92 |
| CHEMBL5086301 | — | — | 1 | 6.85 |
| CHEMBL5069521 | — | — | 1 | 6.75 |
| CHEMBL5090935 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076204 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5092077 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5084942 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5094273 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5093941 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5087722 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5087004 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5092841 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5078067 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5082778 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5086301 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5069521 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5090935 | — | IC50 | = | 240.0 | nM | 6.62 |