Assay Detail
Functional
CHEMBL5039256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS Cov-2 infected in Vero E6 cells assessed as reduction in viral RNA replication measured 24 hrs post infection by qRT-PCR analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.98 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082778 | — | — | 1 | 6.60 |
| CHEMBL5076204 | — | — | 1 | 6.54 |
| CHEMBL5090935 | — | — | 1 | 6.46 |
| CHEMBL5086301 | — | — | 1 | 6.37 |
| CHEMBL5084942 | — | — | 1 | 6.36 |
| CHEMBL5092841 | — | — | 1 | 6.31 |
| CHEMBL5092077 | — | — | 1 | 6.12 |
| CHEMBL5087004 | — | — | 1 | 5.87 |
| CHEMBL5093941 | — | — | 1 | 5.38 |
| CHEMBL5069521 | — | — | 1 | 5.38 |
| CHEMBL5087722 | — | — | 1 | 5.25 |
| CHEMBL5078067 | — | — | 1 | 5.09 |
| CHEMBL5094273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082778 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5076204 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5090935 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5086301 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5084942 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5092841 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5092077 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5087004 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5093941 | — | EC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL5069521 | — | EC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL5087722 | — | EC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL5078067 | — | EC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL5094273 | — | EC50 | > | 2000.0 | nM | - |