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Assay Detail

CHEMBL5039258

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 DE3 using FRET substrate incubated for 10 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Severe acute respiratory syndrome coronavirus 2
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.
Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H.
J Med Chem (2022) 65 : 2794 -2808
PubMed 33872498 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.17 6.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5075209 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5075209 IC50 = 670.0 nM 6.17