Assay Detail
Functional
CHEMBL5040209
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Anti-proliferative activity against human SEM cells harboring MLL/AF4 fusion protein assessed as cell growth inhibition measured after 4 days by Cell Titre Glo Luminescent Cell viability assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.29 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094183 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094183 | — | IC50 | = | 51.0 | nM | 7.29 |