Assay Detail
Functional
CHEMBL5040232
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Anti-cancer activity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.35 | 4.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081321 | — | — | 1 | 4.56 |
| CHEMBL1471 | APREPITANT | 4.0 | 1 | 4.54 |
| CHEMBL5074014 | — | — | 1 | 4.40 |
| CHEMBL5079617 | — | — | 1 | 4.30 |
| CHEMBL5078626 | — | — | 1 | 4.25 |
| CHEMBL5074991 | — | — | 1 | 4.04 |
| CHEMBL5084694 | — | — | 1 | - |
| CHEMBL5083565 | — | — | 1 | - |
| CHEMBL5090998 | — | — | 1 | - |
| CHEMBL5086787 | — | — | 1 | - |
| CHEMBL5078603 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081321 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL1471 | APREPITANT | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL5074014 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL5079617 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL5078626 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL5074991 | — | IC50 | = | 92230.0 | nM | 4.04 |
| CHEMBL5084694 | — | IC50 | = | 155700.0 | nM | - |
| CHEMBL5083565 | — | IC50 | = | 225800.0 | nM | - |
| CHEMBL5090998 | — | IC50 | = | 130800.0 | nM | - |
| CHEMBL5086787 | — | IC50 | = | 503700.0 | nM | - |
| CHEMBL5078603 | — | IC50 | > | 800000.0 | nM | - |