Assay Detail
Functional
CHEMBL5040233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-cancer activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.52 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1471 | APREPITANT | 4.0 | 1 | 4.74 |
| CHEMBL5081321 | — | — | 1 | 4.73 |
| CHEMBL5079617 | — | — | 1 | 4.68 |
| CHEMBL5074014 | — | — | 1 | 4.63 |
| CHEMBL5083565 | — | — | 1 | 4.62 |
| CHEMBL5090998 | — | — | 1 | 4.53 |
| CHEMBL5078626 | — | — | 1 | 4.50 |
| CHEMBL5074991 | — | — | 1 | 4.39 |
| CHEMBL5078603 | — | — | 1 | 4.22 |
| CHEMBL5084694 | — | — | 1 | 4.17 |
| CHEMBL5086787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1471 | APREPITANT | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL5081321 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL5079617 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL5074014 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL5083565 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL5090998 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL5078626 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL5074991 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL5078603 | — | IC50 | = | 59500.0 | nM | 4.22 |
| CHEMBL5084694 | — | IC50 | = | 67500.0 | nM | 4.17 |
| CHEMBL5086787 | — | IC50 | = | 171900.0 | nM | - |