Assay Detail
Functional
CHEMBL5040272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.84 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1471 | APREPITANT | 4.0 | 1 | 8.85 |
| CHEMBL5083565 | — | — | 1 | 6.45 |
| CHEMBL5078626 | — | — | 1 | 6.08 |
| CHEMBL5074991 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1471 | APREPITANT | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL5083565 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5078626 | — | IC50 | = | 833.0 | nM | 6.08 |
| CHEMBL5074991 | — | IC50 | = | 1100.0 | nM | 5.96 |