Assay Detail
Binding
CHEMBL5040285
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Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.91 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091821 | — | — | 1 | 8.22 |
| CHEMBL5088125 | — | — | 1 | 8.05 |
| CHEMBL5093610 | — | — | 1 | 8.00 |
| CHEMBL5081268 | — | — | 1 | 7.96 |
| CHEMBL5081573 | — | — | 1 | 7.75 |
| CHEMBL5078837 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091821 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5088125 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5093610 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5081268 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5081573 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5078837 | — | IC50 | = | 32.0 | nM | 7.50 |