Assay Detail
Binding
CHEMBL5040288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Spike glycoprotein (CHEMBL4662936) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.01 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088125 | — | — | 1 | 7.89 |
| CHEMBL5093610 | — | — | 1 | 7.34 |
| CHEMBL5081573 | — | — | 1 | 6.99 |
| CHEMBL5081268 | — | — | 1 | 6.97 |
| CHEMBL5091821 | — | — | 1 | 6.61 |
| CHEMBL5078837 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088125 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL5093610 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL5081573 | — | Kd | = | 102.0 | nM | 6.99 |
| CHEMBL5081268 | — | Kd | = | 106.0 | nM | 6.97 |
| CHEMBL5091821 | — | Kd | = | 245.0 | nM | 6.61 |
| CHEMBL5078837 | — | Kd | = | 541.0 | nM | 6.27 |