Assay Detail
Binding
CHEMBL5040290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Spike glycoprotein (CHEMBL4662936) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.53 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094981 | — | — | 1 | 5.70 |
| CHEMBL5094988 | — | — | 1 | 5.70 |
| CHEMBL5088895 | — | — | 1 | 5.40 |
| CHEMBL5070871 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094981 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL5094988 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL5088895 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL5070871 | — | Kd | = | 5000.0 | nM | 5.30 |