Assay Detail
Binding
CHEMBL5040906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP51 in Candida albicans ATCC SC5314 measured after 30 mins by HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lanosterol 14-alpha demethylase (CHEMBL1780) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.68 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 6.87 |
| CHEMBL5088292 | — | — | 1 | 6.68 |
| CHEMBL5094280 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5088292 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5094280 | — | IC50 | = | 323.0 | nM | 6.49 |