Assay Detail
Binding
CHEMBL5041176
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Inhibition of wild type human P-gp in human MES-SA/Dx5 cells incubated for 3 days by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.16 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5074763 | — | — | 1 | 8.10 |
| CHEMBL4594298 | ENCEQUIDAR | 3.0 | 1 | 7.96 |
| CHEMBL5076722 | — | — | 1 | 7.85 |
| CHEMBL5076816 | — | — | 1 | 7.75 |
| CHEMBL5075886 | — | — | 1 | 7.46 |
| CHEMBL5081940 | — | — | 1 | 7.41 |
| CHEMBL5081545 | — | — | 1 | 7.41 |
| CHEMBL5083331 | — | — | 1 | 7.39 |
| CHEMBL5077462 | — | — | 1 | 7.31 |
| CHEMBL5075114 | — | — | 1 | 7.30 |
| CHEMBL5090486 | — | — | 1 | 7.21 |
| CHEMBL5076237 | — | — | 1 | 7.04 |
| CHEMBL5094677 | — | — | 1 | 7.03 |
| CHEMBL5072078 | — | — | 1 | 6.68 |
| CHEMBL5073106 | — | — | 1 | 6.65 |
| CHEMBL5079066 | — | — | 1 | 6.30 |
| CHEMBL5074563 | — | — | 1 | 6.00 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.98 |
| CHEMBL5077301 | — | — | 1 | - |
| CHEMBL5074836 | — | — | 1 | - |
| CHEMBL5084749 | — | — | 1 | - |
| CHEMBL5080434 | — | — | 1 | - |
| CHEMBL5094781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5074763 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4594298 | ENCEQUIDAR | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5076722 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5076816 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5075886 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5081940 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5081545 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5083331 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5077462 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5075114 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5090486 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5076237 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5094677 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5072078 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5073106 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL5079066 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL5074563 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 1058.0 | nM | 5.98 |
| CHEMBL5077301 | — | IC50 | > | 1280.0 | nM | - |
| CHEMBL5074836 | — | IC50 | > | 1280.0 | nM | - |
| CHEMBL5084749 | — | IC50 | > | 1280.0 | nM | - |
| CHEMBL5080434 | — | IC50 | > | 1280.0 | nM | - |
| CHEMBL5094781 | — | IC50 | > | 1280.0 | nM | - |