Assay Detail
Binding
CHEMBL5041213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.2 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -95 mV by Qube-automated patch clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 2 subunit alpha (CHEMBL4187) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.82 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318147 | — | — | 1 | 5.82 |
| CHEMBL5085021 | — | — | 1 | - |
| CHEMBL5076349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318147 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5085021 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL5076349 | — | IC50 | > | 17000.0 | nM | - |