Assay Detail
Functional
CHEMBL5041552
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Antiproliferative activity against human RPMI 8226 cells assessed as reduction in cell viability measured after 72 hrs by XTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phytochemical Investigation of the Roots of <i>Ipomoea asarifolia</i> and Antiproliferative Activity of the Isolated Compounds against Multiple Myeloma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.80 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.35 |
| CHEMBL498715 | — | — | 1 | 5.52 |
| CHEMBL447968 | STOLONIFERIN III | — | 1 | 5.11 |
| CHEMBL471797 | — | — | 1 | 5.03 |
| CHEMBL524298 | PESCAPREIN IV | — | 1 | 4.97 |
| CHEMBL5079882 | — | — | 1 | - |
| CHEMBL504178 | PESCAPREIN III | — | 1 | - |
| CHEMBL1773737 | PESCAPREIN XXI | — | 1 | - |
| CHEMBL1773739 | PESCAPREIN XXIII | — | 1 | - |
| CHEMBL1773741 | PESCAPREIN XXV | — | 1 | - |
| CHEMBL1773742 | PESCAPREIN XXVI | — | 1 | - |
| CHEMBL5086549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL498715 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL447968 | STOLONIFERIN III | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL471797 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL524298 | PESCAPREIN IV | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5079882 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL504178 | PESCAPREIN III | IC50 | > | 10000.0 | nM | - |
| CHEMBL1773737 | PESCAPREIN XXI | IC50 | > | 10000.0 | nM | - |
| CHEMBL1773739 | PESCAPREIN XXIII | IC50 | > | 10000.0 | nM | - |
| CHEMBL1773741 | PESCAPREIN XXV | IC50 | > | 10000.0 | nM | - |
| CHEMBL1773742 | PESCAPREIN XXVI | IC50 | > | 10000.0 | nM | - |
| CHEMBL5086549 | — | IC50 | > | 10000.0 | nM | - |