Assay Detail
Functional
CHEMBL5041682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV infected in human Huh7.5 cells incubated for 72 hrs by in-cell western assay
34
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh7.5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 7.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085921 | — | — | 1 | 8.52 |
| CHEMBL5075336 | — | — | 1 | 8.52 |
| CHEMBL5071294 | — | — | 1 | 8.40 |
| CHEMBL5079487 | — | — | 1 | 8.40 |
| CHEMBL5085849 | — | — | 1 | 8.30 |
| CHEMBL5079063 | — | — | 1 | 8.15 |
| CHEMBL5089550 | — | — | 1 | 8.10 |
| CHEMBL5093188 | — | — | 1 | 8.00 |
| CHEMBL5078438 | — | — | 1 | 7.89 |
| CHEMBL5089898 | — | — | 1 | 7.80 |
| CHEMBL5092164 | — | — | 1 | 7.35 |
| CHEMBL5081228 | — | — | 1 | 7.26 |
| CHEMBL5081997 | — | — | 1 | 7.14 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.09 |
| CHEMBL5075495 | — | — | 1 | 7.08 |
| CHEMBL5094177 | — | — | 1 | 7.02 |
| CHEMBL4642093 | — | — | 1 | 6.96 |
| CHEMBL5069476 | — | — | 1 | 6.96 |
| CHEMBL5084859 | — | — | 1 | 6.79 |
| CHEMBL4634954 | — | — | 2 | 6.76 |
| CHEMBL5091946 | — | — | 1 | 6.66 |
| CHEMBL5075353 | — | — | 1 | 6.61 |
| CHEMBL5080317 | — | — | 1 | 6.57 |
| CHEMBL4644538 | — | — | 1 | 6.02 |
| CHEMBL4641538 | — | — | 1 | 5.99 |
| CHEMBL4634675 | — | — | 1 | 5.98 |
| CHEMBL5091541 | — | — | 1 | 5.82 |
| CHEMBL4633946 | — | — | 1 | 5.45 |
| CHEMBL5084608 | — | — | 1 | 4.92 |
| CHEMBL4648991 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085921 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5075336 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5071294 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5079487 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5085849 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5079063 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5089550 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5093188 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5078438 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5089898 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5092164 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5081228 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5081997 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5075495 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5094177 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5069476 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4642093 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5084859 | — | EC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4634954 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4634954 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5091946 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5075353 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5080317 | — | EC50 | = | 271.0 | nM | 6.57 |
| CHEMBL4644538 | — | EC50 | = | 956.0 | nM | 6.02 |
| CHEMBL4641538 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4634675 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL5091541 | — | EC50 | = | 1519.0 | nM | 5.82 |
| CHEMBL4633946 | — | EC50 | = | 3556.0 | nM | 5.45 |
| CHEMBL5084608 | — | EC50 | = | 12164.0 | nM | 4.92 |
| CHEMBL4648991 | — | EC50 | = | 21057.0 | nM | 4.68 |
| CHEMBL5085146 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5087903 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL5088770 | — | EC50 | > | 4000.0 | nM | - |