Assay Detail
Functional
CHEMBL5041685
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Antiviral activity against HCVcc infected in human Huh7.5 cells assessed as inhibition of viral replication
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh7.5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.53 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085849 | — | — | 1 | 8.54 |
| CHEMBL5071294 | — | — | 1 | 8.48 |
| CHEMBL22150 | CHLORCYCLIZINE | 2.0 | 1 | 7.17 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 6.89 |
| CHEMBL4634954 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085849 | — | EC50 | = | 2.89 | nM | 8.54 |
| CHEMBL5071294 | — | EC50 | = | 3.33 | nM | 8.48 |
| CHEMBL22150 | CHLORCYCLIZINE | EC50 | = | 67.56 | nM | 7.17 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 128.66 | nM | 6.89 |
| CHEMBL4634954 | — | EC50 | = | 259.67 | nM | 6.59 |