Assay Detail
Binding
CHEMBL5041809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase binding assay
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 1 (CHEMBL5749) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.26 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5080055 | — | — | 1 | 9.40 |
| CHEMBL5092805 | — | — | 1 | 9.33 |
| CHEMBL5082573 | — | — | 2 | 9.10 |
| CHEMBL5093381 | — | — | 1 | 8.82 |
| CHEMBL5089907 | — | — | 1 | 8.74 |
| CHEMBL5088939 | — | — | 1 | 8.68 |
| CHEMBL5078234 | — | — | 1 | 8.66 |
| CHEMBL5083540 | — | — | 1 | 8.62 |
| CHEMBL5093245 | — | — | 1 | 8.60 |
| CHEMBL5075876 | — | — | 1 | 8.59 |
| CHEMBL5086273 | — | — | 1 | 8.57 |
| CHEMBL5078580 | — | — | 1 | 8.55 |
| CHEMBL5073693 | — | — | 1 | 8.48 |
| CHEMBL5075884 | — | — | 1 | 8.28 |
| CHEMBL5093838 | — | — | 1 | 8.09 |
| CHEMBL5084042 | — | — | 1 | 8.09 |
| CHEMBL5076389 | — | — | 1 | 8.08 |
| CHEMBL5092867 | — | — | 1 | 8.08 |
| CHEMBL5093710 | — | — | 1 | 7.96 |
| CHEMBL5087625 | — | — | 1 | 7.85 |
| CHEMBL5069623 | — | — | 1 | 7.55 |
| CHEMBL5092646 | — | — | 1 | 7.48 |
| CHEMBL5078498 | — | — | 1 | 7.37 |
| CHEMBL5079859 | — | — | 1 | 7.20 |
| CHEMBL5092507 | — | — | 1 | 7.18 |
| CHEMBL5079401 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5080055 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL5092805 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL5082573 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL5093381 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL5089907 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL5082573 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5088939 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL5078234 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL5083540 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL5093245 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL5075876 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL5086273 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL5078580 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL5073693 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL5075884 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL5093838 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL5084042 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL5092867 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL5076389 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL5093710 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5087625 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5069623 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL5092646 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL5078498 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL5079859 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL5092507 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL5079401 | — | Ki | = | 85.0 | nM | 7.07 |