Assay Detail
Binding
CHEMBL5041858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and measured after 30 min by fluorescence spectrophotometer analysis
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-<i>C</i>-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.82 | 8.33 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5028005 | — | — | 1 | 8.33 |
| CHEMBL5028265 | — | — | 1 | 8.21 |
| CHEMBL5029066 | — | — | 1 | 7.72 |
| CHEMBL5027974 | — | — | 1 | 7.43 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 7.23 |
| CHEMBL5028138 | — | — | 1 | 7.23 |
| CHEMBL75971 | — | — | 1 | 7.23 |
| CHEMBL1651551 | — | — | 1 | 7.02 |
| CHEMBL1651550 | — | — | 1 | 6.89 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 6.70 |
| CHEMBL5080975 | — | — | 1 | 6.68 |
| CHEMBL1651549 | — | — | 1 | 6.68 |
| CHEMBL5080744 | — | — | 1 | 6.44 |
| CHEMBL5028105 | — | — | 1 | 5.60 |
| CHEMBL5028084 | — | — | 1 | 5.22 |
| CHEMBL5028072 | — | — | 1 | 4.43 |
| CHEMBL175901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5028005 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL5028265 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL5029066 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL5027974 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL307429 | DUVOGLUSTAT | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL5028138 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL75971 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1651551 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1651550 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1029 | MIGLUSTAT | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL5080975 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1651549 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL5080744 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL5028105 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL5028084 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL5028072 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL175901 | — | Inhibition | - | % | - |