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Assay Detail

CHEMBL5041865

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Sucrase (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sucrase-isomaltase, intestinal (CHEMBL2748)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

5-<i>C</i>-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease.
Kato A, Nakagome I, Kanekiyo U, Lu TT, Li YX, Yoshimura K, Kishida M, Shinzawa K, Yoshida T, Tanaka N, Jia YM, Nash RJ, Fleet GWJ, Yu CY.
J Med Chem (2022) 65 : 2329 -2341
PubMed 35072486 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL406973 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL406973 IC50 = 1000.0 nM 6.00