Assay Detail
Binding
CHEMBL5041876
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Inhibition of human soluble CD73 assessed as inhibition constant
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.56 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081267 | — | — | 1 | 9.36 |
| CHEMBL5083600 | — | — | 1 | 9.36 |
| CHEMBL5074970 | — | — | 1 | 9.29 |
| CHEMBL5078828 | — | — | 1 | 9.20 |
| CHEMBL5080841 | — | — | 1 | 9.17 |
| CHEMBL5086866 | — | — | 1 | 9.07 |
| CHEMBL5076916 | — | — | 1 | 9.05 |
| CHEMBL5084248 | — | — | 1 | 8.97 |
| CHEMBL5081442 | — | — | 1 | 8.94 |
| CHEMBL5081604 | — | — | 1 | 8.90 |
| CHEMBL5079813 | — | — | 1 | 8.80 |
| CHEMBL5094601 | — | — | 1 | 8.79 |
| CHEMBL5076275 | — | — | 1 | 8.75 |
| CHEMBL5089752 | — | — | 1 | 8.75 |
| CHEMBL5076684 | — | — | 1 | 8.60 |
| CHEMBL5070874 | — | — | 1 | 8.58 |
| CHEMBL5093165 | — | — | 1 | 8.46 |
| CHEMBL5092522 | — | — | 1 | 7.85 |
| CHEMBL5077925 | — | — | 1 | 7.23 |
| CHEMBL5083016 | — | — | 1 | 7.15 |
| CHEMBL3606064 | — | — | 1 | 5.59 |
| CHEMBL5075093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081267 | — | Ki | = | 0.436 | nM | 9.36 |
| CHEMBL5083600 | — | Ki | = | 0.441 | nM | 9.36 |
| CHEMBL5074970 | — | Ki | = | 0.511 | nM | 9.29 |
| CHEMBL5078828 | — | Ki | = | 0.626 | nM | 9.20 |
| CHEMBL5080841 | — | Ki | = | 0.673 | nM | 9.17 |
| CHEMBL5086866 | — | Ki | = | 0.848 | nM | 9.07 |
| CHEMBL5076916 | — | Ki | = | 0.894 | nM | 9.05 |
| CHEMBL5084248 | — | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL5081442 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL5081604 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL5079813 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL5094601 | — | Ki | = | 1.63 | nM | 8.79 |
| CHEMBL5076275 | — | Ki | = | 1.76 | nM | 8.75 |
| CHEMBL5089752 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL5076684 | — | Ki | = | 2.51 | nM | 8.60 |
| CHEMBL5070874 | — | Ki | = | 2.613 | nM | 8.58 |
| CHEMBL5093165 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL5092522 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL5077925 | — | Ki | = | 59.2 | nM | 7.23 |
| CHEMBL5083016 | — | Ki | = | 71.5 | nM | 7.15 |
| CHEMBL3606064 | — | Ki | = | 2540.0 | nM | 5.59 |
| CHEMBL5075093 | — | Ki | > | 50000.0 | nM | - |