Assay Detail
Binding
CHEMBL5042312
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Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (CHEMBL3860) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.52 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1387422 | — | — | 1 | 8.10 |
| CHEMBL5092661 | — | — | 1 | 8.07 |
| CHEMBL5084153 | — | — | 1 | 8.03 |
| CHEMBL5089219 | — | — | 1 | 7.87 |
| CHEMBL5094121 | — | — | 1 | 7.58 |
| CHEMBL5077941 | — | — | 1 | 7.54 |
| CHEMBL5086138 | — | — | 1 | 7.41 |
| CHEMBL5079726 | — | — | 1 | 7.39 |
| CHEMBL5087129 | — | — | 1 | 7.35 |
| CHEMBL5083136 | — | — | 1 | 7.35 |
| CHEMBL5072868 | — | — | 1 | 7.31 |
| CHEMBL5084808 | — | — | 1 | 6.88 |
| CHEMBL5082602 | — | — | 1 | 6.83 |
| CHEMBL5092958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1387422 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5092661 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL5084153 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL5089219 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL5094121 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL5077941 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5086138 | — | Ki | = | 38.8 | nM | 7.41 |
| CHEMBL5079726 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL5087129 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL5083136 | — | Ki | = | 44.4 | nM | 7.35 |
| CHEMBL5072868 | — | Ki | = | 49.3 | nM | 7.31 |
| CHEMBL5084808 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL5082602 | — | Ki | = | 146.5 | nM | 6.83 |
| CHEMBL5092958 | — | Ki | > | 1000.0 | nM | - |