Assay Detail
Binding
CHEMBL5042339
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Inhibition of Mycobacterium abscessus DNA gyrase using pBR322 DNA as substrate measured after 2 days by fluorescence based microplate reader assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacteroides abscessus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship of Anti-<i>Mycobacterium abscessus</i> Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.57 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085925 | — | — | 1 | 6.96 |
| CHEMBL5072749 | — | — | 1 | 5.82 |
| CHEMBL5084804 | — | — | 1 | 5.82 |
| CHEMBL3317856 | GEPOTIDACIN | 3.0 | 1 | 5.70 |
| CHEMBL5071218 | — | — | 1 | 5.52 |
| CHEMBL3637783 | — | — | 1 | 5.52 |
| CHEMBL5091986 | — | — | 1 | 5.52 |
| CHEMBL5091038 | — | — | 1 | 5.22 |
| CHEMBL5079578 | — | — | 1 | 5.22 |
| CHEMBL5069966 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085925 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5072749 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5084804 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3317856 | GEPOTIDACIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5071218 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3637783 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5091986 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5091038 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5079578 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5069966 | — | IC50 | = | 40000.0 | nM | 4.40 |