Assay Detail
Binding
CHEMBL5042363
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Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective A<sub>3</sub> Adenosine Receptor Antagonist Radioligand for Human and Rodent Species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.76 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181976 | — | — | 1 | 8.78 |
| CHEMBL5086258 | — | — | 1 | 8.21 |
| CHEMBL5081520 | — | — | 1 | 8.20 |
| CHEMBL5088750 | — | — | 1 | 7.72 |
| CHEMBL5078378 | — | — | 1 | 7.58 |
| CHEMBL111545 | — | — | 1 | 7.36 |
| CHEMBL5086466 | — | — | 1 | 7.16 |
| CHEMBL5073183 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181976 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL5086258 | — | Ki | = | 6.12 | nM | 8.21 |
| CHEMBL5081520 | — | Ki | = | 6.34 | nM | 8.20 |
| CHEMBL5088750 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL5078378 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL111545 | — | Ki | = | 43.9 | nM | 7.36 |
| CHEMBL5086466 | — | Ki | = | 69.2 | nM | 7.16 |
| CHEMBL5073183 | — | Ki | = | 80.7 | nM | 7.09 |