Assay Detail
Binding
CHEMBL5042388
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Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in HEK293 cells by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective A<sub>3</sub> Adenosine Receptor Antagonist Radioligand for Human and Rodent Species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.41 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 9.43 |
| CHEMBL88147 | — | — | 1 | 8.53 |
| CHEMBL5073355 | — | — | 1 | 7.97 |
| CHEMBL464859 | NECA | — | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL88147 | — | Ki | = | 2.97 | nM | 8.53 |
| CHEMBL5073355 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL464859 | NECA | Ki | = | 19.6 | nM | 7.71 |