Assay Detail
Binding
CHEMBL5042863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an <i>N</i>-acylated-<sup>D</sup>Arg-Leu-NH<sub>2</sub> Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.88 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165920 | — | — | 1 | 11.00 |
| CHEMBL429731 | — | — | 1 | 10.22 |
| CHEMBL5093771 | — | — | 1 | 9.14 |
| CHEMBL5090293 | — | — | 1 | 8.37 |
| CHEMBL5085324 | — | — | 1 | 8.33 |
| CHEMBL5071745 | — | — | 1 | 8.20 |
| CHEMBL5075638 | — | — | 1 | 8.18 |
| CHEMBL5074999 | — | — | 1 | 8.14 |
| CHEMBL2208303 | — | — | 1 | 8.14 |
| CHEMBL5082175 | — | — | 1 | 8.00 |
| CHEMBL5091013 | — | — | 1 | 7.95 |
| CHEMBL1672380 | — | — | 1 | 7.85 |
| CHEMBL5088703 | — | — | 1 | 7.80 |
| CHEMBL5084208 | — | — | 1 | 7.68 |
| CHEMBL5087609 | — | — | 1 | 7.50 |
| CHEMBL5093184 | — | — | 1 | 7.41 |
| CHEMBL5082273 | — | — | 1 | 7.24 |
| CHEMBL4776204 | — | — | 1 | 7.24 |
| CHEMBL5088429 | — | — | 1 | 7.17 |
| CHEMBL2208304 | — | — | 1 | 7.14 |
| CHEMBL5082270 | — | — | 1 | 7.10 |
| CHEMBL5091693 | — | — | 1 | 6.88 |
| CHEMBL5076959 | — | — | 1 | 6.28 |
| CHEMBL5085023 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165920 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL429731 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL5093771 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL5090293 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL5085324 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL5071745 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL5075638 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL5074999 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL2208303 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL5082175 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5091013 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL1672380 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5088703 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL5084208 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5087609 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL5093184 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL5082273 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4776204 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL5088429 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL2208304 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL5082270 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL5091693 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL5076959 | — | Ki | = | 523.0 | nM | 6.28 |
| CHEMBL5085023 | — | Ki | = | 591.0 | nM | 6.23 |