Assay Detail
Binding
CHEMBL5042867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-1DMeNPFF from mouse NPFF2R receptor by TopCount scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an <i>N</i>-acylated-<sup>D</sup>Arg-Leu-NH<sub>2</sub> Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.36 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429731 | — | — | 1 | 8.96 |
| CHEMBL4776204 | — | — | 1 | 6.08 |
| CHEMBL5074999 | — | — | 1 | 5.84 |
| CHEMBL5091013 | — | — | 1 | 5.56 |
| CHEMBL5085324 | — | — | 1 | 5.37 |
| CHEMBL2165920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429731 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4776204 | — | Ki | = | 824.0 | nM | 6.08 |
| CHEMBL5074999 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL5091013 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL5085324 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL2165920 | — | Ki | - | — | - |