Assay Detail
Binding
CHEMBL5042989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-arginine-vasopressin from human V2 receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 1321N1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Characterization of New V<sub>1A</sub> Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.60 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344159 | TOLVAPTAN | 4.0 | 1 | 9.00 |
| CHEMBL5070075 | — | — | 1 | 6.70 |
| CHEMBL5070261 | — | — | 1 | 6.33 |
| CHEMBL4799793 | — | — | 1 | 6.25 |
| CHEMBL5074709 | — | — | 1 | 6.05 |
| CHEMBL5081323 | — | — | 1 | 5.97 |
| CHEMBL4297183 | BALOVAPTAN | 3.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344159 | TOLVAPTAN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5070075 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL5070261 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL4799793 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL5074709 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL5081323 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL4297183 | BALOVAPTAN | Ki | = | 1200.0 | nM | 5.92 |