Assay Detail
Binding
CHEMBL5043007
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Inhibition of recombinant C-terminal His-tagged SARS coronavirus 1 3CL protease using Boc-Abu-Tle-Leu-Gln-AMC as substrate incubated for 5 mins by Cheng-Prusoff equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.08 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316746 | — | — | 1 | 8.39 |
| CHEMBL2435614 | — | — | 1 | 8.20 |
| CHEMBL2435605 | — | — | 1 | 7.66 |
| CHEMBL553172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316746 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL2435614 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL2435605 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL553172 | — | Ki | = | 135000.0 | nM | - |