Assay Detail
Functional
CHEMBL5043048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS Cov-2 USA_WA1/2020 infected in Vero E6 cells expressing ACE2 reporter assessed as reduction in plaque formation at 0.21 to 50 uM and measured at 3 days post-infection by crystal violet staining based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL<sup>pro</sup>).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.39 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061258 | — | — | 1 | 6.37 |
| CHEMBL5087481 | — | — | 1 | 6.25 |
| CHEMBL5092107 | — | — | 1 | 5.76 |
| CHEMBL5076577 | — | — | 1 | 5.70 |
| CHEMBL5094026 | — | — | 1 | 5.49 |
| CHEMBL5075864 | — | — | 1 | 5.48 |
| CHEMBL5090994 | — | — | 1 | 5.47 |
| CHEMBL5081675 | — | — | 1 | 5.33 |
| CHEMBL5092270 | — | — | 1 | 5.12 |
| CHEMBL5075764 | — | — | 1 | 4.95 |
| CHEMBL2442056 | — | — | 1 | 4.84 |
| CHEMBL5081793 | — | — | 1 | 4.78 |
| CHEMBL2442081 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061258 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5087481 | — | EC50 | = | 558.0 | nM | 6.25 |
| CHEMBL5092107 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5076577 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5094026 | — | EC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL5075864 | — | EC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL5090994 | — | EC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL5081675 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL5092270 | — | EC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL5075764 | — | EC50 | = | 11140.0 | nM | 4.95 |
| CHEMBL2442056 | — | EC50 | = | 14550.0 | nM | 4.84 |
| CHEMBL5081793 | — | EC50 | = | 16690.0 | nM | 4.78 |
| CHEMBL2442081 | — | EC50 | = | 28150.0 | nM | 4.55 |