Assay Detail
Functional
CHEMBL5043049
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Antiviral activity against SARS Cov-2 USA_WA1/2020 infected in Vero E6 cells expressing ACE2 reporter assessed as inhibition of viral cytopathic effect measured after 68 hrs post infection by neutral red uptake assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL<sup>pro</sup>).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.51 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061258 | — | — | 1 | 6.47 |
| CHEMBL5087481 | — | — | 1 | 6.30 |
| CHEMBL5092107 | — | — | 1 | 5.76 |
| CHEMBL5090994 | — | — | 1 | 5.72 |
| CHEMBL5075864 | — | — | 1 | 5.70 |
| CHEMBL5076577 | — | — | 1 | 5.64 |
| CHEMBL5094026 | — | — | 1 | 5.53 |
| CHEMBL5081675 | — | — | 1 | 5.42 |
| CHEMBL5092270 | — | — | 1 | 5.24 |
| CHEMBL5075764 | — | — | 1 | 5.12 |
| CHEMBL5081793 | — | — | 1 | 5.06 |
| CHEMBL2442056 | — | — | 1 | 4.92 |
| CHEMBL2442081 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061258 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5087481 | — | EC50 | = | 497.0 | nM | 6.30 |
| CHEMBL5092107 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL5090994 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5075864 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL5076577 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5094026 | — | EC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL5081675 | — | EC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5092270 | — | EC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL5075764 | — | EC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL5081793 | — | EC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL2442056 | — | EC50 | = | 12070.0 | nM | 4.92 |
| CHEMBL2442081 | — | EC50 | = | 19900.0 | nM | 4.70 |