Assay Detail
Binding
CHEMBL5043069
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Inhibition of DHPS (unknown origin ) incubated for 30 mins by NAD/NADH-Glow assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.58 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091313 | — | — | 1 | 7.85 |
| CHEMBL5079375 | — | — | 1 | 7.40 |
| CHEMBL5074971 | — | — | 1 | 7.30 |
| CHEMBL5075342 | — | — | 1 | 7.00 |
| CHEMBL5091281 | — | — | 1 | 6.75 |
| CHEMBL5084409 | — | — | 1 | 6.75 |
| CHEMBL5090481 | — | — | 1 | 6.50 |
| CHEMBL5078063 | — | — | 1 | 6.48 |
| CHEMBL5091279 | — | — | 1 | 6.28 |
| CHEMBL5070084 | — | — | 1 | 6.25 |
| CHEMBL5081296 | — | — | 1 | 6.19 |
| CHEMBL5075319 | — | — | 1 | 5.93 |
| CHEMBL229457 | — | — | 1 | 5.76 |
| CHEMBL5089864 | — | — | 1 | 5.64 |
| CHEMBL5080635 | — | — | 1 | 5.62 |
| CHEMBL5080971 | — | — | 1 | 5.37 |
| CHEMBL5073964 | — | — | 1 | 5.36 |
| CHEMBL5078229 | — | — | 1 | 5.26 |
| CHEMBL5091549 | — | — | 1 | 4.93 |
| CHEMBL5081865 | — | — | 1 | 4.89 |
| CHEMBL5092133 | — | — | 1 | 4.74 |
| CHEMBL5089522 | — | — | 1 | 4.70 |
| CHEMBL5069826 | — | — | 1 | 4.47 |
| CHEMBL5072102 | — | — | 1 | 4.45 |
| CHEMBL5081207 | — | — | 1 | 4.42 |
| CHEMBL5092168 | — | — | 1 | 4.41 |
| CHEMBL5083806 | — | — | 1 | 4.27 |
| CHEMBL5083278 | — | — | 1 | 4.23 |
| CHEMBL957 | BOSENTAN | 4.0 | 1 | 4.22 |
| CHEMBL5091437 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091313 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5079375 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5074971 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5075342 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5091281 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5084409 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5090481 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5078063 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5091279 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5070084 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5081296 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5075319 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL229457 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL5089864 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5080635 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL5080971 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5073964 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL5078229 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL5091549 | — | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL5081865 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5092133 | — | IC50 | = | 18210.0 | nM | 4.74 |
| CHEMBL5089522 | — | IC50 | = | 19990.0 | nM | 4.70 |
| CHEMBL5069826 | — | IC50 | = | 33690.0 | nM | 4.47 |
| CHEMBL5072102 | — | IC50 | = | 35790.0 | nM | 4.45 |
| CHEMBL5081207 | — | IC50 | = | 38130.0 | nM | 4.42 |
| CHEMBL5092168 | — | IC50 | = | 38680.0 | nM | 4.41 |
| CHEMBL5083806 | — | IC50 | = | 53650.0 | nM | 4.27 |
| CHEMBL5083278 | — | IC50 | = | 59100.0 | nM | 4.23 |
| CHEMBL957 | BOSENTAN | IC50 | = | 60830.0 | nM | 4.22 |
| CHEMBL5091437 | — | IC50 | = | 80000.0 | nM | 4.10 |