Assay Detail
Functional
CHEMBL5043071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse B16 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.80 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081296 | — | — | 1 | 5.52 |
| CHEMBL5091313 | — | — | 1 | 5.35 |
| CHEMBL5091279 | — | — | 1 | 5.34 |
| CHEMBL5073964 | — | — | 1 | 5.30 |
| CHEMBL229457 | — | — | 1 | 5.28 |
| CHEMBL5091281 | — | — | 1 | 5.27 |
| CHEMBL5081207 | — | — | 1 | 5.11 |
| CHEMBL5084409 | — | — | 1 | 5.07 |
| CHEMBL5091549 | — | — | 1 | 4.93 |
| CHEMBL5078229 | — | — | 1 | 4.93 |
| CHEMBL5069826 | — | — | 1 | 4.88 |
| CHEMBL5081865 | — | — | 1 | 4.86 |
| CHEMBL5083278 | — | — | 1 | 4.76 |
| CHEMBL5089522 | — | — | 1 | 4.75 |
| CHEMBL5076676 | — | — | 1 | 4.74 |
| CHEMBL5075342 | — | — | 1 | 4.73 |
| CHEMBL5089864 | — | — | 1 | 4.71 |
| CHEMBL5070084 | — | — | 1 | 4.69 |
| CHEMBL5078063 | — | — | 1 | 4.68 |
| CHEMBL5080971 | — | — | 1 | 4.66 |
| CHEMBL5093523 | — | — | 1 | 4.66 |
| CHEMBL5079375 | — | — | 1 | 4.63 |
| CHEMBL5072102 | — | — | 1 | 4.61 |
| CHEMBL5092168 | — | — | 1 | 4.56 |
| CHEMBL5091437 | — | — | 1 | 4.52 |
| CHEMBL5080635 | — | — | 1 | 4.52 |
| CHEMBL5083806 | — | — | 1 | 4.51 |
| CHEMBL5074971 | — | — | 1 | 4.41 |
| CHEMBL5090481 | — | — | 1 | 4.32 |
| CHEMBL5092133 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081296 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL5091313 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL5091279 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL5073964 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL229457 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL5091281 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5081207 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL5084409 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL5091549 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL5078229 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL5069826 | — | IC50 | = | 13090.0 | nM | 4.88 |
| CHEMBL5081865 | — | IC50 | = | 13820.0 | nM | 4.86 |
| CHEMBL5083278 | — | IC50 | = | 17410.0 | nM | 4.76 |
| CHEMBL5089522 | — | IC50 | = | 17910.0 | nM | 4.75 |
| CHEMBL5076676 | — | IC50 | = | 18110.0 | nM | 4.74 |
| CHEMBL5075342 | — | IC50 | = | 18790.0 | nM | 4.73 |
| CHEMBL5089864 | — | IC50 | = | 19590.0 | nM | 4.71 |
| CHEMBL5070084 | — | IC50 | = | 20270.0 | nM | 4.69 |
| CHEMBL5078063 | — | IC50 | = | 20890.0 | nM | 4.68 |
| CHEMBL5080971 | — | IC50 | = | 21940.0 | nM | 4.66 |
| CHEMBL5093523 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL5079375 | — | IC50 | = | 23620.0 | nM | 4.63 |
| CHEMBL5072102 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL5092168 | — | IC50 | = | 27640.0 | nM | 4.56 |
| CHEMBL5091437 | — | IC50 | = | 30450.0 | nM | 4.52 |
| CHEMBL5080635 | — | IC50 | = | 30090.0 | nM | 4.52 |
| CHEMBL5083806 | — | IC50 | = | 31140.0 | nM | 4.51 |
| CHEMBL5074971 | — | IC50 | = | 39140.0 | nM | 4.41 |
| CHEMBL5090481 | — | IC50 | = | 47400.0 | nM | 4.32 |
| CHEMBL5092133 | — | IC50 | = | 47840.0 | nM | 4.32 |
| CHEMBL5075319 | — | IC50 | = | 70850.0 | nM | 4.15 |
| CHEMBL957 | BOSENTAN | IC50 | > | 80000.0 | nM | - |