Assay Detail
Functional
CHEMBL5043073
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Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.33 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091313 | — | — | 1 | 7.85 |
| CHEMBL5075342 | — | — | 1 | 6.92 |
| CHEMBL229457 | — | — | 1 | 6.10 |
| CHEMBL5091281 | — | — | 1 | 5.90 |
| CHEMBL5091279 | — | — | 1 | 5.50 |
| CHEMBL5078063 | — | — | 1 | 5.49 |
| CHEMBL5080971 | — | — | 1 | 5.39 |
| CHEMBL5073964 | — | — | 1 | 5.38 |
| CHEMBL5091549 | — | — | 1 | 5.36 |
| CHEMBL5092168 | — | — | 1 | 5.33 |
| CHEMBL5084409 | — | — | 1 | 5.21 |
| CHEMBL5074971 | — | — | 1 | 5.06 |
| CHEMBL5070084 | — | — | 1 | 4.95 |
| CHEMBL5090481 | — | — | 1 | 4.85 |
| CHEMBL5075319 | — | — | 1 | 4.83 |
| CHEMBL5089522 | — | — | 1 | 4.71 |
| CHEMBL5080635 | — | — | 1 | 4.70 |
| CHEMBL5081296 | — | — | 1 | 4.50 |
| CHEMBL5069826 | — | — | 1 | 4.27 |
| CHEMBL957 | BOSENTAN | 4.0 | 1 | 4.27 |
| CHEMBL5083806 | — | — | 1 | - |
| CHEMBL5081207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091313 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5075342 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL229457 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5091281 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5091279 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL5078063 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5080971 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL5073964 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL5091549 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5092168 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL5084409 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL5074971 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL5070084 | — | IC50 | = | 11180.0 | nM | 4.95 |
| CHEMBL5090481 | — | IC50 | = | 14010.0 | nM | 4.85 |
| CHEMBL5075319 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL5089522 | — | IC50 | = | 19440.0 | nM | 4.71 |
| CHEMBL5080635 | — | IC50 | = | 20140.0 | nM | 4.70 |
| CHEMBL5081296 | — | IC50 | = | 31940.0 | nM | 4.50 |
| CHEMBL5069826 | — | IC50 | = | 53950.0 | nM | 4.27 |
| CHEMBL957 | BOSENTAN | IC50 | = | 53650.0 | nM | 4.27 |
| CHEMBL5083806 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5081207 | — | IC50 | > | 80000.0 | nM | - |