Assay Detail
Binding
CHEMBL5043133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.95 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764751 | — | — | 1 | 7.40 |
| CHEMBL4796938 | — | — | 1 | 7.28 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4796938 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL51085 | EBSELEN | IC50 | = | 670.0 | nM | 6.17 |