Assay Detail
Binding
CHEMBL5043162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2/cyclin E1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.52 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786320 | — | — | 1 | 7.38 |
| CHEMBL4786555 | — | — | 1 | 7.28 |
| CHEMBL4791134 | — | — | 1 | 7.11 |
| CHEMBL4555799 | — | — | 1 | 6.99 |
| CHEMBL4786843 | — | — | 1 | 6.89 |
| CHEMBL5088381 | — | — | 1 | 6.72 |
| CHEMBL4782954 | — | — | 1 | 6.55 |
| CHEMBL4779443 | — | — | 1 | 6.52 |
| CHEMBL5083688 | — | — | 1 | 6.46 |
| CHEMBL4786592 | — | — | 1 | 6.38 |
| CHEMBL4790490 | — | — | 1 | 6.34 |
| CHEMBL5080711 | — | — | 1 | 6.11 |
| CHEMBL4800180 | — | — | 1 | 6.04 |
| CHEMBL4798916 | — | — | 1 | 5.79 |
| CHEMBL5090754 | SY-5609 | 1.0 | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786320 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4786555 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4791134 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4555799 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4786843 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5088381 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4782954 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL4779443 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL5083688 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL4786592 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL4790490 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5080711 | — | IC50 | = | 771.0 | nM | 6.11 |
| CHEMBL4800180 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL4798916 | — | IC50 | = | 1638.0 | nM | 5.79 |
| CHEMBL5090754 | SY-5609 | IC50 | = | 5524.0 | nM | 5.26 |