Assay Detail
Functional
CHEMBL5043163
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Antiproliferative activity against human HCC70 cells incubated for 72 hrs by Celltiter-glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC70 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.87 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786592 | — | — | 1 | 9.70 |
| CHEMBL5080711 | — | — | 1 | 9.00 |
| CHEMBL5090754 | SY-5609 | 1.0 | 1 | 9.00 |
| CHEMBL5088381 | — | — | 1 | 8.05 |
| CHEMBL4786320 | — | — | 1 | 7.96 |
| CHEMBL4791134 | — | — | 1 | 7.85 |
| CHEMBL4782954 | — | — | 1 | 7.82 |
| CHEMBL5083688 | — | — | 1 | 7.44 |
| CHEMBL4555799 | — | — | 1 | 7.40 |
| CHEMBL4779443 | — | — | 1 | 7.05 |
| CHEMBL4800180 | — | — | 1 | 6.64 |
| CHEMBL4798916 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786592 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5080711 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5090754 | SY-5609 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5088381 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4786320 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4791134 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4782954 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5083688 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4555799 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4779443 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4800180 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4798916 | — | EC50 | = | 287.0 | nM | 6.54 |