Assay Detail

CHEMBL5043300

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Binding

Inhibition of CD63 (unknown origin) assessed as FcepsilonR induced basophil activation

ChEMBL ↗

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Target

CD63 antigen (CHEMBL3713303) ↗

Open DB target context

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CD63 antigen (CHEMBL3713303) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target CD63 antigen

CHEMBL3713303

Anchored from Assay target.

Protein identity CD63 antigen

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

CD63 antigen (CHEMBL3713303) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.

Hopkins BT, Bame E, Bajrami B, Black C, Bohnert T, Boiselle C, Burdette D, Burns JC, Delva L, Donaldson D, Grater R, Gu C, Hoemberger M, Johnson J, Kapadnis S, King K, Lulla M, Ma B, Marx I, Magee T, Meissner R, Metrick CM, Mingueneau M, Murugan P, Otipoby KL, Polack E, Poreci U, Prince R, Roach AM, Rowbottom C, Santoro JC, Schroeder P, Tang H, Tien E, Zhang F, Lyssikatos J.
J Med Chem (2022) 65 : 1206 -1224
PubMed 34734694 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.09	7.09

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5083772	BIIB-091	2.0	1	7.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5083772	BIIB-091	IC50	=	82.0	nM	7.09